(Rev. 11:8 "...the great city...where also our Lord was crucified...."), the seat of Judaism, in the first century and until its destruction in 70AD, was a primary source of persecution of the disciples of Jesus. From the opposition to and crucifixion of Jesus Himself, to the jailing, scourging, and killing of apostles and other Christians, Jerusalem led the way in opposing the saints. The apostle Paul, before his conversion, was a chief instrument of this cruelty toward the followers of Christ (Acts 22:4-5 "I persecuted this Way to the death....").
The city of Jerusalem is to taste God's wrath in the book of Revelation. The prophecies concerning this city resulted in its utter destruction by the Romans in 70AD.